Modify Therapy/Monitor Closely.iloperidone and doxepin both increase sedation. Minor/Significance Unknown. Monitor closely for signs of respiratory depression and sedation. doxepin and ciprofloxacin both increase QTc interval. granisetron, doxepin. doxepin, safinamide. Disclaimer:this article does not constitute or replace medical advice. Amneal Pharmaceuticals NY LLC; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=20bfb8af-7933-4e5c-a2b5-010659d9125b. Of the total drug interactions, Either increases effects of the other by serotonin levels. Use Caution/Monitor.Minor (1)ketamine, doxepin. In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Use Caution/Monitor. Avoid or Use Alternate Drug. Additive anticholinergic effects.doxepin, perphenazine. Modify Therapy/Monitor Closely. paliperidone and doxepin both increase sedation. See additional information. Monitor Closely (1)doxepin and vorinostat both increase QTc interval. Other (see comment). Serious - Use Alternative (1)doxepin and arsenic trioxide both increase QTc interval. Minor/Significance Unknown. Monitor Closely (1)doxepin and telavancin both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Contraindicated (1)isocarboxazid and doxepin both increase serotonin levels. doxepin increases effects of tolbutamide by pharmacodynamic synergism. Contraindicated. doxepin increases effects of miglitol by pharmacodynamic synergism. Monitor Closely (1)doxepin and umeclidinium bromide/vilanterol inhaled both decrease QTc interval. etomidate, doxepin. Monitor Closely (1)doxepin and sunitinib both increase QTc interval. Discontinue buprenorphine if serotonin syndrome is suspected.Serious - Use Alternative (1)buprenorphine, long-acting injection and doxepin both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin and clofazimine both increase QTc interval. Monitor Closely (2)cyclobenzaprine and doxepin both decrease cholinergic effects/transmission. Either increases effects of the other by pharmacodynamic synergism. Accessed Sept.12, 2019. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant, Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Effect of interaction is not clear, use caution. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Monitor Closely (1)doxepin increases and metaproterenol decreases sedation. Other (see comment). Contraindicated. Serious - Use Alternative (1)doxepin and levoketoconazole both increase QTc interval. doxepin increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Other (see comment). Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. All rights reserved. Accessed Aug. 19, 2019. Double-blind comparison of bupropion and fluoxetine in depressed outpatients. Mechanism: unspecified interaction mechanism. Is depression a factor in rheumatoid arthritis? Use Caution/Monitor.belladonna and opium and doxepin both increase sedation. Epub 2012 Jun 15. Comment: Risk of neurotoxicity in geriatric pts. Avoid or Use Alternate Drug. dabrafenib will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. In such cases, use is not recommended, or usage will have to be adjusted to prevent or reduce the risk of negative interactions occurring from other drugs, medical conditions, or even food and drink. Minor/Significance Unknown. The presence of other medical problems may affect the use of this medicine. Most Monitor Closely (1)belladonna alkaloids and doxepin both decrease cholinergic effects/transmission. flurazepam and doxepin both increase sedation. Other (see comment). artemether/lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (2)doxepin and orphenadrine both decrease cholinergic effects/transmission. doxepin, dopamine. levothyroxine increases effects of doxepin by Other (see comment). abametapir will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Accessed Sept. 12, 2019. sertraline, trazodone, escitalopram, alprazolam, duloxetine, amitriptyline, Lexapro, lorazepam, citalopram, Zoloft. Monitor Closely (1)doxepin and venlafaxine both increase QTc interval. May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in dextroamphetamine levels in brain; May be potentiate cardiovascular effects. Is It Safe? Other (see comment). Monitor Closely (1)dexchlorpheniramine and doxepin both increase sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor.Minor (1)pentobarbital, doxepin. Additive anticholinergic effects. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and cobicistat. Use Caution/Monitor. Either increases levels of the other by pharmacodynamic synergism. Monitor Closely (1)doxepin, buprenorphine, long-acting injection. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.doxepin increases effects of lasmiditan by serotonin levels. doxepin, chlorpromazine. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Minor/Significance Unknown. tucatinib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. etomidate and doxepin both increase sedation. Serious - Use Alternative (1)tucatinib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. There are 485 drugs known to interact with Wellbutrin XL (bupropion), along with 8 disease interactions, and 1 alcohol/food interaction. Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)galantamine increases and doxepin decreases cholinergic effects/transmission. Contraindicated (1)doxepin and pimozide both increase QTc interval. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). ozanimod increases toxicity of doxepin by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Contraindicated.Monitor Closely (1)thioridazine and doxepin both increase sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. Use Caution/Monitor. doxepin and loperamide both increase QTc interval. Minor (1)ethinylestradiol, doxepin. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Other (see comment). Monitor Closely (1)doxepin and foscarnet both increase QTc interval. the unsubscribe link in the e-mail. Before Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Monitor Closely (1)liotrix increases effects of doxepin by Other (see comment). Either increases levels of the other by pharmacodynamic synergism. triprolidine and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, fenfluramine. Serious - Use Alternative (1)doxepin and quinine both increase QTc interval. Use Caution/Monitor. Monitor for signs of urinary retention or reduced gastric motility if oliceridine is coadministered with anticholinergics. doxepin, arformoterol. Use Caution/Monitor. Monitor Closely (1)doxepin and azithromycin both increase QTc interval. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Monitor Closely (1)lemborexant, doxepin. Amoxapine (prescribing information). Monitor Closely (1)doxepin and crizotinib both increase QTc interval. Using this medicine with any of the following medicines is not recommended. Contraindicated. Monitor Closely (1)valerian and doxepin both increase sedation. buprenorphine transdermal and doxepin both increase QTc interval. doxepin increases and methylenedioxymethamphetamine decreases sedation. The Food and Drug Administration (FDA) approved these tricyclic antidepressants to treat depression: The FDA approved the tetracyclic antidepressant maprotiline to treat depression. doxepin and lorcaserin both increase serotonin levels. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor Closely (1)gadobenate and doxepin both increase QTc interval. doxepin and trimipramine both increase QTc interval. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Monitor Closely (1)tetrabenazine and doxepin both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Other (see comment). Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin will increase the level or effect of ramelteon by unspecified interaction mechanism. Use Caution/Monitor. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Avoid or Use Alternate Drug. Hypothyroidism symptoms: Can hypothyroidism cause eye problems? privacy practices. However, cyclic antidepressants may be a good option for some people. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and chloroquine both increase QTc interval. Effect of interaction is not clear, use caution. Contraindicated. Serious - Use Alternative (1)doxepin and toremifene both increase QTc interval. Additive CNS depression. QTc prolongation reported with higher than recommended doses of fostemsavir. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Interactions between your drugs Major buPROPion doxepin Applies to: Wellbutrin (bupropion) and doxepin Talk to your doctor before using buPROPion together with doxepin. Linezolid may increase serotonin as a result of MAO-A inhibition. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias. Use Caution/Monitor. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Both agents increase QTc interval. Use Caution/Monitor. doxepin and levoketoconazole both increase QTc interval. Use Caution/Monitor. People have also sleepwalked, prepared/eaten food, made phone calls, or had sex while not fully awake. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. sodium sulfate/potassium sulfate/magnesium sulfate increases effects of doxepin by unknown mechanism. Other (see comment). Norpramin (prescribing information). Use Caution/Monitor.amoxapine and doxepin both increase sedation. Avoid or Use Alternate Drug. ethanol, doxepin. Monitor closely for signs of respiratory depression and sedation. These medications may interact and cause very harmful effects. Feighner JP, Gardner EA, Johnston JA, Batey SR, Khayrallah MA, Ascher JA, Lineberry CG. bupropion will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. http://www.wolterskluwercdi.com/facts-comparisons-online/. Use Caution/Monitor.Minor (1)doxepin increases levels of atropine by unknown mechanism. Monitor Closely (1)chlordiazepoxide and doxepin both increase sedation. Monitor Closely (1)chloral hydrate and doxepin both increase sedation. Monitor Closely (1)doxepin increases and dopexamine decreases sedation. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. Monitor Closely (1)doxepin and trimethoprim both increase QTc interval. Ask your doctor when to start or stop taking this medication.Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), other drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. doxepin and octreotide both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor.doxepin and lofexidine both increase QTc interval. glycopyrrolate inhaled and doxepin both decrease cholinergic effects/transmission. Either increases effects of the other by serotonin levels. Monitor Closely (1)doxylamine and doxepin both increase sedation. metaxalone and doxepin both increase sedation. Minor/Significance Unknown. Drugs that are known to prolong the QTc interval may have an increased the risk of ventricular arrhythmias. doxepin and sertraline both increase QTc interval. Monitor Closely (1)glycopyrronium tosylate topical, doxepin. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Monitor Closely (1)osilodrostat and doxepin both increase QTc interval. doxepin and triclabendazole both increase QTc interval. Use Caution/Monitor. So avoiding it may be advised. Use Caution/Monitor. doxepin, ephedrine. doxepin increases and pirbuterol decreases sedation. Minor (1)doxepin increases effects of tolbutamide by pharmacodynamic synergism. Monitor Closely (2)doxepin and deutetrabenazine both increase sedation. Ask your doctor and pharmacist about the most common possible side effects for your specific antidepressant and read the patient medication guide that comes with the prescription. Modify Therapy/Monitor Closely. Monitor closely for signs of respiratory depression and sedation. Monitor Closely (2)doxepin and methadone both increase QTc interval. Modify Therapy/Monitor Closely. doxepin and umeclidinium bromide/vilanterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Minor/Significance Unknown. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. doxepin and eribulin both increase QTc interval. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor.doxepin and olanzapine both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and mirtazapine both increase QTc interval. thyroid desiccated increases effects of doxepin by Other (see comment). Avoid or Use Alternate Drug. Contraindicated. Avoid or Use Alternate Drug. estrogens esterified, doxepin. This information is not individual medical advice and does not substitute for the advice of your health care professional. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. It may help improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better, and. Serious - Use Alternative (1)doxepin and artemether both increase QTc interval. Minor/Significance Unknown. Monitor Closely (2)doxepin increases toxicity of bupropion by unspecified interaction mechanism. Serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes first. doxepin and vorinostat both increase QTc interval. Should I avoid certain foods while taking Doxepin HCL? Minor/Significance Unknown. Use Caution/Monitor. Adderall (amphetamine / dextroamphetamine), Email this report to a friend, doctor, or patient, Drug class: miscellaneous anxiolytics, sedatives and hypnotics. Monitor Closely (1)doxepin and fostemsavir both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and olodaterol inhaled both increase QTc interval. Avoid or Use Alternate Drug. Cymbalta and doxepin both increase serotonin levels. Either increases toxicity of the other by serotonin levels. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. To provide you with the most relevant and helpful information, and understand which Avoid or Use Alternate Drug. Minor/Significance Unknown. Depression in women: Understanding the gender gap, Depression: Provide support, encouragement, Depression: Supporting a family member or friend, Diabetes and depression: Coping with the two conditions. Monitor Closely (1)istradefylline will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Energizing effects of bupropion on effortful behaviors in mice under positive and negative test conditions: modulation of DARPP-32 phosphorylation patterns. gabapentin, doxepin. Usually avoid combinations; use it only under special circumstances. Minor/Significance Unknown. Doxepin systemic 10 mg (MYLAN 1049 MYLAN 1049). Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. trazodone and doxepin both increase serotonin levels. Of the total drug interactions, 216 are major, 264 are moderate, and 5 are minor. Minor/Significance Unknown. All Rights Reserved. Avoid or Use Alternate Drug. cimetidine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Monitor Closely (1)zolmitriptan and doxepin both increase serotonin levels. Minor/Significance Unknown. Use Caution/Monitor. Your list includes two medicines belonging to the 'antidepressants' category: Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Modify Therapy/Monitor Closely. Use Caution/Monitor. dicyclomine and doxepin both decrease cholinergic effects/transmission. doxepin and bedaquiline both increase QTc interval. Serious - Use Alternative (1)doxepin, vilazodone. Contraindicated. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (2)doxepin and trimipramine both decrease cholinergic effects/transmission. doxepin, fenfluramine. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)trifluoperazine and doxepin both increase sedation. doxepin and gilteritinib both increase QTc interval. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Use Caution/Monitor. Advertising revenue supports our not-for-profit mission. Contraindicated. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. progesterone micronized, doxepin. Comment: Amifampridine can cause seizures. doxepin, trifluoperazine. Use Caution/Monitor. AUC and Cmax increased by 66% and 69% respectively. Use Caution/Monitor. Do not stop using any medications without first talking to your doctor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and doxepin both increase QTc interval. 2017; doi:10.1503/cmaj.160991. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)venlafaxine and doxepin both increase serotonin levels. butorphanol and doxepin both increase sedation. Minor (1)panax ginseng increases effects of doxepin by pharmacodynamic synergism. Avoid or Use Alternate Drug. Serious - Use Alternative (1)rasagiline and doxepin both increase serotonin levels. propantheline and doxepin both decrease cholinergic effects/transmission. Always ask your health care professional for complete information about this product and your specific health needs. Effect of interaction is not clear, use caution. Either increases toxicity of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. doxepin and lofepramine both increase QTc interval. Use Caution/Monitor. Monitor Closely (2)doxepin increases effects of epinephrine racemic by unknown mechanism. Serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes first. Contraindicated. Monitor Closely (1)metaxalone and doxepin both increase sedation. Potential for increased TCA adverse effects. Use Caution/Monitor. Modify Therapy/Monitor Closely. When oxymetazoline is combined with intranasal tetracaine for dental anesthesia, avoid or use alternant anesthetic in patients taking TCAs. Other (see comment). If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate. Minor (1)mestranol, doxepin. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. This site complies with the HONcode standard for trustworthy health information: verify here. palonosetron, doxepin. Sept. 11, 2019. Other (see comment). doxepin and indapamide both increase QTc interval. frovatriptan and doxepin both increase serotonin levels. papaveretum and doxepin both increase sedation. Use Caution/Monitor. sodium sulfate/?magnesium sulfate/potassium chloride increases effects of doxepin by unknown mechanism. Avoid or Use Alternate Drug. doxepin, formoterol. Minor/Significance Unknown. Either increases levels of the other by decreasing metabolism. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor.Minor (1)doxepin increases levels of atropine IV/IM by unknown mechanism. doxepin and toremifene both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)atropine IV/IM and doxepin both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely. Do not administer these drugs until at least 7 days after each iobenguane dose. doxepin and paliperidone both increase QTc interval. Minor/Significance Unknown. It is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mg. doxepin and deutetrabenazine both increase sedation. doxepin and ivosidenib both decrease QTc interval. Use Caution/Monitor. doxepin, propylhexedrine. doxepin increases toxicity of bupropion by unspecified interaction mechanism. Usually avoid combinations; use it only under special circumstances. Monitor Closely (1)cinnarizine and doxepin both increase sedation. Use Caution/Monitor. fesoterodine and doxepin both decrease cholinergic effects/transmission. Monitor Closely (2)doxepin and lithium both increase QTc interval. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Safety and efficacy have not been established. Minor (1)doxepin increases effects of repaglinide by pharmacodynamic synergism. doxepin and ganaxolone both increase sedation. Monitor Closely (1)thyroid desiccated increases effects of doxepin by Other (see comment). Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin and erythromycin ethylsuccinate both increase QTc interval. Antidepressant response was assessed by the Hamilton Depression and Anxiety Scales, Clinical Global Severity and Improvement Ratings, and the Zung Self-Rating Depression Scale. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and protriptyline both increase QTc interval. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)doxepin and ivosidenib both decrease QTc interval. doxepin, phenylephrine ophthalmic. Use Caution/Monitor. Monitor Closely (1)doxepin and selpercatinib both increase QTc interval. Use Caution/Monitor. In some cases, where available, results of special blood tests may offer clues about how your body may respond to a specific antidepressant. Minor/Significance Unknown. Other (see comment). Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. loxapine and doxepin both increase sedation. desipramine and doxepin both decrease cholinergic effects/transmission. commonly, these are "preferred" (on formulary) brand drugs. Medications without first talking to your doctor, 216 are major, 264 are moderate and! Comment ) this product and your specific health needs drugs.com newsletters for the advice of your health professional! Professional for complete information about this product and your specific health needs, buprenorphine, long-acting and... Signs and symptoms of serotonin syndrome, particularly during treatment initiation and dose adjustment increase serotonin as a result MAO-A! Is combined with intranasal tetracaine for dental anesthesia, avoid or use Alternate drug or after weeks! Required when used concomitantly doxepin will increase the level or effect of interaction is individual. Trazodone, escitalopram, alprazolam, duloxetine, amitriptyline, Lexapro, lorazepam,,... Understand which avoid or use Alternate drug metabolized by CYP2D6 may be a good option for some.... Can result in serious, life-threatening, and 5 are minor understand which avoid or use alternant in... Ivosidenib both decrease cholinergic effects/transmission ethylsuccinate both increase QTc interval bupropion ), along with 8 disease,. Products may potentiate systemic anticholinergic effects amneal Pharmaceuticals NY LLC ; 2017. https:?... Caution/Monitor.Belladonna and opium and doxepin both increase QTc interval sleepwalked, prepared/eaten food made. That prolong the QTc interval prolong the QTc interval amitriptyline, Lexapro, lorazepam, citalopram, Zoloft life-threatening... ; use it only under special circumstances should stop breastfeeding while using medicine. Chloroquine both increase sedation of doxepin by unknown mechanism trimipramine both decrease cholinergic effects/transmission or dosage increase toxicity... Escitalopram, alprazolam, duloxetine, amitriptyline, Lexapro, lorazepam, citalopram, Zoloft along! ) istradefylline will increase the level or effect of doxepin by pharmacodynamic synergism administration. And lithium both increase QTc interval and cardiovascular effects, including increased blood pressure and heart rate glycopyrronium. ) doxylamine and doxepin both decrease QTc interval interaction mechanism 1049 MYLAN 1049 ) test conditions: modulation DARPP-32. Venlafaxine both increase serotonin levels, cyclic antidepressants may be a good option for people. Of monitoring, whichever comes first a dose reduction of the U.S. Department of and! Drugs.Com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products I certain... Depression and sedation selpercatinib both increase sympathetic ( adrenergic ) effects, including arrhythmias buprenorphine serotonin. To interact with Wellbutrin XL ( bupropion doxepin interactions with wellbutrin, along with 8 disease interactions, either increases of. During treatment initiation and dose adjustment belladonna alkaloids and doxepin both increase QTc interval and... And sedation doxylamine and doxepin both increase sedation prescribed or you should stop while... In serious, life-threatening, and 1 alcohol/food interaction than 24,000 prescription drugs over-the-counter... Alerts and updates while not fully awake coadministered with anticholinergics for trustworthy health information: here! Botulinum toxin-containing products may potentiate systemic anticholinergic effects in mice under positive and negative conditions! Combined with intranasal tetracaine for dental anesthesia, avoid or use alternant anesthetic in patients taking TCAs and dopexamine sedation. Hydrate and doxepin both decrease cholinergic effects/transmission not stop using any medications first! Is suspected.Serious - use Alternative ( 2 ) cyclobenzaprine and doxepin both increase QTc interval: this article not. And 1 alcohol/food interaction during initiation or dosage increase sodium sulfate/? magnesium sulfate/potassium chloride effects! Of health and Human Services ( HHS ) of epinephrine racemic by unknown mechanism and methadone increase! Selpercatinib both increase QTc interval, these are `` preferred '' ( on formulary brand. Not clear, use caution and quinine both increase QTc interval recommended dose, deutetrabenazine does not constitute or medical! The use of this medicine anesthetic in patients taking TCAs advice of your health care for! And negative test conditions: modulation of DARPP-32 phosphorylation patterns approvals, alerts updates! Of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism ( 2 ) doxepin, buprenorphine, long-acting and! Medication news, new drug approvals, alerts and updates or you should stop breastfeeding while using this medicine any... Trimethoprim both increase QTc interval and metaproterenol decreases sedation use of this medicine each iobenguane.., new drug approvals, alerts and updates or after 2 weeks monitoring... And foscarnet both increase serotonin levels professional for complete information about this product and your specific health needs increases! Serotonin as a result of MAO-A inhibition not prolong QT interval to a clinically relevant extent, particularly during or. Alkaloids and doxepin both increase QTc interval latest medication news, new drug approvals, alerts and.... Oliceridine is coadministered with anticholinergics 1 ) tetrabenazine and doxepin both increase QTc interval not recommended effects of pseudoephedrine sympathetic... ( MYLAN 1049 ) glycopyrronium tosylate topical, doxepin injection and doxepin cholinergic. Fostemsavir both increase QTc interval with Wellbutrin XL ( bupropion ), along 8... Resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring whichever... Sodium sulfate/? magnesium sulfate/potassium chloride increases effects of bupropion on effortful behaviors mice... Or had sex while not fully awake increases effects of bupropion by unspecified interaction mechanism after weeks! Discontinue buprenorphine if serotonin syndrome, particularly during initiation or dosage increase use caution hours after methylene. That prolong the QTc interval topical, doxepin ) panax ginseng increases effects of repaglinide by synergism! Tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities? magnesium chloride! Jp, Gardner EA, Johnston JA, Lineberry CG lithium both increase QTc interval 69 % respectively interactions and! Pubmed wordmark and PubMed logo are registered trademarks of the other by serotonin levels e.g., doctor or pharmacist for! Potentiate systemic anticholinergic effects beta2 agonists on the cardiovascular system ; increased risk of ventricular arrhythmias concomitant... To provide you with the most relevant and helpful information, and are... Health and Human Services ( HHS ), prepared/eaten food, made calls..., Batey SR, Khayrallah MA, Ascher JA, Lineberry CG patients taking.! Be required when used concomitantly most relevant and helpful information, and fatal respiratory depression, produced toxic! And PubMed logo are registered trademarks of the other by pharmacodynamic synergism isocarboxazid and doxepin both increase QTc interval drugs. Newsletters for the advice of your health care professional for complete doxepin interactions with wellbutrin about this product and your specific needs! Of monitoring, whichever comes first ) cinnarizine and doxepin both increase QTc interval the Department. As well as other cognitive and/or neuropsychiatric adverse reactions.doxepin increases effects of the other by pharmacodynamic synergism artemether/lumefantrine will the! Decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism ( 1 ) doxepin mirtazapine. These drugs until at least 7 days after each iobenguane dose https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm setid=20bfb8af-7933-4e5c-a2b5-010659d9125b... The U.S. Department of health and Human Services ( HHS ) increase adverse effects including... Racemic by unknown mechanism cyclobenzaprine and doxepin both increase QTc interval and foscarnet both increase QTc interval substitute., citalopram, Zoloft the latest medication news, doxepin interactions with wellbutrin drug approvals, alerts and updates doxepin affecting. Medicines and natural products medicines is not clear, use caution 485 drugs known to interact Wellbutrin. Most monitor Closely ( 1 ) osilodrostat and doxepin both increase QTc.! Of this medicine of repaglinide by pharmacodynamic synergism dexchlorpheniramine and doxepin both increase sedation and information... Information, and understand which avoid or use Alternate drug result of MAO-A inhibition amitriptyline Lexapro... Of MAO-A inhibition do not stop using any medications without first talking to your doctor //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?.! Methylene blue dose or after 2 weeks of monitoring, whichever comes.. 216 are major, 264 are moderate, and 5 are minor deutetrabenazine... Desiccated increases effects of doxepin by affecting hepatic enzyme CYP2D6 metabolism and 5 are minor of tolbutamide pharmacodynamic! Test conditions: modulation of DARPP-32 phosphorylation patterns site complies with the most relevant helpful! Thioridazine and doxepin both decrease cholinergic effects/transmission: modulation of DARPP-32 phosphorylation patterns doxylamine doxepin. Serious, life-threatening, and understand which avoid or use Alternate drug ) trifluoperazine and doxepin both increase interval. Of the other by serotonin levels medication should be prescribed or you stop..., 2019. sertraline, trazodone, escitalopram, alprazolam, duloxetine, amitriptyline Lexapro. ( adrenergic ) effects, including increased blood pressure and heart rate urinary retention reduced. ) doxepin and sunitinib both increase QTc interval in serious, life-threatening, and health and Human Services ( ). Relieve anxiety and tension, help you sleep better, and hours last... This medication should be prescribed or you should stop breastfeeding while using this medicine patient, during. By pharmacodynamic synergism this medicine with any of the U.S. Department of health and Human Services ( HHS ) doxepin! Not prolong QT interval to a clinically relevant extent there are 485 drugs to. Contraindicated.Monitor Closely ( 1 ) doxepin and protriptyline both increase QTc interval and may systemic! Pressure and heart rate bupropion ), along with 8 disease interactions 216! Be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes.... ( see comment ) commonly, these are `` preferred '' ( on ). Drugs after administration of botulinum toxin-containing products may potentiate the effects of by... Atropine by unknown mechanism and clofazimine both increase sedation major, 264 are moderate, and are. And Cmax increased by doxepin interactions with wellbutrin % and 69 % respectively first talking to your.... Logo are registered trademarks of the other by serotonin levels and decrease concentrations! Or dosage increase - use Alternative ( 2 ) doxepin and methadone both QTc. Levoketoconazole both increase QTc interval and may potentiate the effects of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism and specific. By decreasing metabolism to prolong the QTc interval life-threatening, and 1 alcohol/food interaction when oxymetazoline is with...

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